TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals
نویسندگان
چکیده
منابع مشابه
TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet.
BACKGROUND Transcription factor 7-like 2 (TCF7L2) rs7903146 associates with type 2 diabetes and may operate via impaired glucagon-like peptide 1 secretion, which is stimulated more by fat than by carbohydrate ingestion. OBJECTIVE The objective was to examine the interaction between TCF7L2 rs7903146 and dietary fat and carbohydrate [high-fat, low-carbohydrate: 40-45% of energy as fat (HF); com...
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Background: Due to the increasing number of stressful life events among the elderly and the rapid spread of diabetes among them, the present study compared the stressful life events of diabetic elderly with those of non-diabetic elderly. Materials and Methods: This descriptive, cross-sectional study was conducted on 240 senior citizens of over 60 years of age (120 diabetic patients and 120 n...
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BACKGROUND Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory chain function and mitochondrial dynamics. More recent publications also described a link between Parkin and mitophagy. METHODOLOGY/PRINCIPAL FINDINGS In this study, we investiga...
متن کاملEffects of rs7903146 Variation in the Tcf7l2 Gene in the Lipid Metabolism of Three Different Populations
BACKGROUND TCF7L2 rs7903146 is an important genetic factor predicting type 2 diabetes (T2DM) which has also been linked to higher cardiovascular risk. To date, there is little information about the additional impact of this single nucleotide polymorphism (SNP) beyond glucose metabolism. METHODOLOGY/PRINCIPAL FINDINGS We studied whether rs7903146 influenced postprandial lipid metabolism in thr...
متن کاملRole of the single nucleotide polymorphism rs7903146 of TCF7L2 in inducing nonsense-mediated decay
BACKGROUND The single nucleotide polymorphism (SNP) rs7903146 (C/T), located in intron 4 of the transcription factor 7-like 2 gene (TCF7L2), has been associated with an increased risk of developing Type 2 Diabetes, although the molecular mechanism remain elusive. The TCF7L2 gene is alternatively spliced but an association between genotype and splice variants has not been shown convincingly. We ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2012
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-012-2660-8